Why Drug Discovery is Hard (and How You Can Help)

Enoch Huang

Pfizer

I will provide an overview of the drug discovery process and the scientific challenges associated with bringing novel therapies to the patient. The steep odds and punishing attrition rates characteristic of traditional drug discovery have increased the demand for computational approaches for improved target selection and compound design. I will suggest areas where the efforts of computer scientists working with biological knowledge can play a key role in generating mechanistic insights for toxicity, physiology, and disease.

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