Gene expression analysis: A knowledge-based approach
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Jill P. Mesirov
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Broad Institute of MIT and Harvard
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DNA microarrays now make it possible to capture the expression pattern
of all the genes in the genome in a single experiment.   Genome-wide
expression analysis is at the heart of global genomic approaches to
biomedical research and appears in over 5000 published papers a year.
The challenge that now faces us is not obtaining these molecular
profiles, but interpreting them to gain a better understanding of
underlying biological processes.  We will describe how prior biological
knowledge can be incorporated into a robust, quantitative approach to
analyzing mRNA profile data.
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