Gene expression analysis: A knowledge-based approach
Jill P. Mesirov
Broad Institute of MIT and Harvard
DNA microarrays now make it possible to capture the expression pattern of all the genes in the genome in a single experiment. Genome-wide expression analysis is at the heart of global genomic approaches to biomedical research and appears in over 5000 published papers a year. The challenge that now faces us is not obtaining these molecular profiles, but interpreting them to gain a better understanding of underlying biological processes. We will describe how prior biological knowledge can be incorporated into a robust, quantitative approach to analyzing mRNA profile data.
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