Datasetgse25507_collapsed_to_symbols.gse25507.gpl570.cls
#N_versus_Y.gse25507.gpl570.cls
#N_versus_Y_repos
Phenotypegse25507.gpl570.cls#N_versus_Y_repos
Upregulated in classN
GeneSetANTIGEN PROCESSING AND PRESENTATION OF PEPTIDE ANTIGEN VIA MHC CLASS I
Enrichment Score (ES)0.5381526
Normalized Enrichment Score (NES)1.7173059
Nominal p-value0.033613447
FDR q-value1.0
FWER p-Value0.995
Table: GSEA Results Summary



Fig 1: Enrichment plot: ANTIGEN PROCESSING AND PRESENTATION OF PEPTIDE ANTIGEN VIA MHC CLASS I   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1SEC24BSEC24B
Entrez,  Source
SEC24 related gene family, member B (S. cerevisiae)750.2410.0359Yes
2CYBBCYBB
Entrez,  Source
cytochrome b-245, beta polypeptide (chronic granulomatous disease)970.2300.0727Yes
3PSMB9PSMB9
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)2940.1970.0955Yes
4CYBACYBA
Entrez,  Source
cytochrome b-245, alpha polypeptide5220.1750.1131Yes
5CD36CD36
Entrez,  Source
CD36 molecule (thrombospondin receptor)5430.1730.1405Yes
6FCGR1AFCGR1A
Entrez,  Source
Fc fragment of IgG, high affinity Ia, receptor (CD64)7190.1600.1583Yes
7PDIA3PDIA3
Entrez,  Source
protein disulfide isomerase family A, member 39630.1480.1708Yes
8CTSSCTSS
Entrez,  Source
cathepsin S12570.1350.1787Yes
9SEC61GSEC61G
Entrez,  Source
Sec61 gamma subunit12830.1340.1995Yes
10PSMC6PSMC6
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, ATPase, 612880.1340.2213Yes
11SEC61A2SEC61A2
Entrez,  Source
Sec61 alpha 2 subunit (S. cerevisiae)13660.1310.2391Yes
12PSMA3PSMA3
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 314130.1300.2582Yes
13PSMD12PSMD12
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1215100.1270.2743Yes
14NCF4NCF4
Entrez,  Source
neutrophil cytosolic factor 4, 40kDa16360.1230.2883Yes
15PSMD10PSMD10
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1017600.1190.3018Yes
16ITGAVITGAV
Entrez,  Source
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)18420.1160.3170Yes
17IFI30IFI30
Entrez,  Source
interferon, gamma-inducible protein 3019650.1130.3295Yes
18PSMB2PSMB2
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 221390.1080.3388Yes
19PSMA4PSMA4
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 425110.0990.3369Yes
20SEC23ASEC23A
Entrez,  Source
Sec23 homolog A (S. cerevisiae)25690.0970.3501Yes
21PSMB10PSMB10
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 1026490.0950.3619Yes
22LNPEPLNPEP
Entrez,  Source
leucyl/cystinyl aminopeptidase26790.0950.3761Yes
23NCF2NCF2
Entrez,  Source
neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2)27730.0930.3867Yes
24PSMB8PSMB8
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)29210.0890.3942Yes
25SEC61BSEC61B
Entrez,  Source
Sec61 beta subunit30230.0870.4036Yes
26PSMD5PSMD5
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 530300.0870.4176Yes
27PSMA2PSMA2
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 230890.0860.4288Yes
28PSMB3PSMB3
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 331050.0850.4421Yes
29SEC24DSEC24D
Entrez,  Source
SEC24 related gene family, member D (S. cerevisiae)32710.0820.4476Yes
30SEC24ASEC24A
Entrez,  Source
SEC24 related gene family, member A (S. cerevisiae)32730.0820.4611Yes
31TAP2TAP2
Entrez,  Source
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)32960.0820.4735Yes
32TAP1TAP1
Entrez,  Source
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)33890.0800.4821Yes
33SAR1BSAR1B
Entrez,  Source
SAR1 gene homolog B (S. cerevisiae)34370.0790.4928Yes
34UBCUBC
Entrez,  Source
ubiquitin C36720.0740.4936Yes
35PSMB7PSMB7
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 738720.0710.4955Yes
36PSMF1PSMF1
Entrez,  Source
proteasome (prosome, macropain) inhibitor subunit 1 (PI31)40260.0670.4991Yes
37HLA-EHLA-E
Entrez,  Source
major histocompatibility complex, class I, E40760.0660.5076Yes
38UBE2AUBE2A
Entrez,  Source
ubiquitin-conjugating enzyme E2A (RAD6 homolog)41830.0640.5130Yes
39PSMD14PSMD14
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1446150.0570.5014Yes
40PSME1PSME1
Entrez,  Source
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)46710.0560.5080Yes
41HLA-FHLA-F
Entrez,  Source
major histocompatibility complex, class I, F46980.0560.5159Yes
42PSMD9PSMD9
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 948080.0540.5195Yes
43PSMD7PSMD7
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog)51830.0480.5092Yes
44PSMD13PSMD13
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1352360.0480.5145Yes
45PSMB6PSMB6
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 654210.0450.5129Yes
46PSMD3PSMD3
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 355490.0430.5137Yes
47PSME4PSME4
Entrez,  Source
proteasome (prosome, macropain) activator subunit 456060.0420.5178Yes
48HLA-AHLA-A
Entrez,  Source
major histocompatibility complex, class I, A56260.0420.5237Yes
49PSMA5PSMA5
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 557230.0400.5256Yes
50HLA-GHLA-G
Entrez,  Source
HLA-G histocompatibility antigen, class I, G57810.0390.5293Yes
51PSMD8PSMD8
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 858240.0390.5336Yes
52PSME2PSME2
Entrez,  Source
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)58610.0380.5382Yes
53PSMD6PSMD6
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 663280.0320.5207No
54PSMA7PSMA7
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 765450.0290.5150No
55PSME3PSME3
Entrez,  Source
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)66660.0280.5138No
56PSMB4PSMB4
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 473620.0190.4830No
57PSMA6PSMA6
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 673690.0190.4858No
58TPP2TPP2
Entrez,  Source
tripeptidyl peptidase II73810.0190.4883No
59PSMC1PSMC1
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, ATPase, 174250.0180.4891No
60PSMA8PSMA8
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 875940.0160.4835No
61CALRCALR
Entrez,  Source
calreticulin75970.0160.4860No
62PSMD2PSMD2
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 277240.0140.4822No
63PSMC2PSMC2
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, ATPase, 277680.0140.4824No
64PSMD4PSMD4
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 478480.0130.4807No
65HLA-CHLA-C
Entrez,  Source
major histocompatibility complex, class I, C81600.0090.4669No
66BCAP31BCAP31
Entrez,  Source
B-cell receptor-associated protein 3181820.0080.4673No
67PSMB1PSMB1
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 184590.0050.4546No
68PSMD11PSMD11
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1186110.0030.4478No
69SEC31ASEC31A
Entrez,  Source
SEC31 homolog A (S. cerevisiae)86310.0030.4473No
70HLA-BHLA-B
Entrez,  Source
major histocompatibility complex, class I, B87310.0020.4428No
71UBA52UBA52
Entrez,  Source
ubiquitin A-52 residue ribosomal protein fusion product 18957-0.0010.4320No
72TAPBPTAPBP
Entrez,  Source
TAP binding protein (tapasin)9030-0.0020.4288No
73PSMA1PSMA1
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 19405-0.0060.4115No
74CANXCANX
Entrez,  Source
calnexin9528-0.0070.4067No
75BLMHBLMH
Entrez,  Source
bleomycin hydrolase9547-0.0070.4071No
76B2MB2M
Entrez,  Source
beta-2-microglobulin9578-0.0080.4069No
77PSMB5PSMB5
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 59941-0.0120.3911No
78NPEPPSNPEPPS
Entrez,  Source
aminopeptidase puromycin sensitive10733-0.0210.3560No
79UBBUBB
Entrez,  Source
ubiquitin B11292-0.0270.3332No
80PSMC3PSMC3
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, ATPase, 311720-0.0320.3176No
81PSMD1PSMD1
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 113035-0.0460.2611No
82PSMC5PSMC5
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, ATPase, 513791-0.0540.2332No
83RPS27ARPS27A
Entrez,  Source
ribosomal protein S27a14405-0.0620.2135No
84SEC61A1SEC61A1
Entrez,  Source
Sec61 alpha 1 subunit (S. cerevisiae)15029-0.0690.1945No
85ITGB5ITGB5
Entrez,  Source
integrin, beta 517272-0.1010.1018No
86SEC24CSEC24C
Entrez,  Source
SEC24 related gene family, member C (S. cerevisiae)17684-0.1080.0996No
87CD207CD207
Entrez,  Source
CD207 molecule, langerin18298-0.1200.0894No
88ACEACE
Entrez,  Source
angiotensin I converting enzyme (peptidyl-dipeptidase A) 119128-0.1400.0720No
Table: GSEA details [plain text format]



Fig 2: ANTIGEN PROCESSING AND PRESENTATION OF PEPTIDE ANTIGEN VIA MHC CLASS I   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: ANTIGEN PROCESSING AND PRESENTATION OF PEPTIDE ANTIGEN VIA MHC CLASS I: Random ES distribution   
Gene set null distribution of ES for ANTIGEN PROCESSING AND PRESENTATION OF PEPTIDE ANTIGEN VIA MHC CLASS I