Dataset | gse25507_collapsed_to_symbols.gse25507.gpl570.cls #N_versus_Y.gse25507.gpl570.cls #N_versus_Y_repos |
Phenotype | gse25507.gpl570.cls#N_versus_Y_repos |
Upregulated in class | N |
GeneSet | ANTIGEN PROCESSING AND PRESENTATION OF EXOGENOUS PEPTIDE ANTIGEN VIA MHC CLASS I, TAP-DEPENDENT |
Enrichment Score (ES) | 0.5547463 |
Normalized Enrichment Score (NES) | 1.6959057 |
Nominal p-value | 0.0373444 |
FDR q-value | 1.0 |
FWER p-Value | 0.999 |
PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
---|---|---|---|---|---|---|---|
1 | CYBB | CYBB Entrez,  Source | cytochrome b-245, beta polypeptide (chronic granulomatous disease) | 97 | 0.230 | 0.0434 | Yes |
2 | PSMB9 | PSMB9 Entrez,  Source | proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) | 294 | 0.197 | 0.0749 | Yes |
3 | CYBA | CYBA Entrez,  Source | cytochrome b-245, alpha polypeptide | 522 | 0.175 | 0.1003 | Yes |
4 | CD36 | CD36 Entrez,  Source | CD36 molecule (thrombospondin receptor) | 543 | 0.173 | 0.1354 | Yes |
5 | FCGR1A | FCGR1A Entrez,  Source | Fc fragment of IgG, high affinity Ia, receptor (CD64) | 719 | 0.160 | 0.1604 | Yes |
6 | PDIA3 | PDIA3 Entrez,  Source | protein disulfide isomerase family A, member 3 | 963 | 0.148 | 0.1795 | Yes |
7 | SEC61G | SEC61G Entrez,  Source | Sec61 gamma subunit | 1283 | 0.134 | 0.1920 | Yes |
8 | PSMC6 | PSMC6 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, ATPase, 6 | 1288 | 0.134 | 0.2198 | Yes |
9 | SEC61A2 | SEC61A2 Entrez,  Source | Sec61 alpha 2 subunit (S. cerevisiae) | 1366 | 0.131 | 0.2435 | Yes |
10 | PSMA3 | PSMA3 Entrez,  Source | proteasome (prosome, macropain) subunit, alpha type, 3 | 1413 | 0.130 | 0.2683 | Yes |
11 | PSMD12 | PSMD12 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 | 1510 | 0.127 | 0.2901 | Yes |
12 | NCF4 | NCF4 Entrez,  Source | neutrophil cytosolic factor 4, 40kDa | 1636 | 0.123 | 0.3096 | Yes |
13 | PSMD10 | PSMD10 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 | 1760 | 0.119 | 0.3285 | Yes |
14 | ITGAV | ITGAV Entrez,  Source | integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) | 1842 | 0.116 | 0.3488 | Yes |
15 | PSMB2 | PSMB2 Entrez,  Source | proteasome (prosome, macropain) subunit, beta type, 2 | 2139 | 0.108 | 0.3569 | Yes |
16 | PSMA4 | PSMA4 Entrez,  Source | proteasome (prosome, macropain) subunit, alpha type, 4 | 2511 | 0.099 | 0.3594 | Yes |
17 | PSMB10 | PSMB10 Entrez,  Source | proteasome (prosome, macropain) subunit, beta type, 10 | 2649 | 0.095 | 0.3727 | Yes |
18 | NCF2 | NCF2 Entrez,  Source | neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2) | 2773 | 0.093 | 0.3860 | Yes |
19 | PSMB8 | PSMB8 Entrez,  Source | proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) | 2921 | 0.089 | 0.3975 | Yes |
20 | SEC61B | SEC61B Entrez,  Source | Sec61 beta subunit | 3023 | 0.087 | 0.4108 | Yes |
21 | PSMD5 | PSMD5 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 | 3030 | 0.087 | 0.4287 | Yes |
22 | PSMA2 | PSMA2 Entrez,  Source | proteasome (prosome, macropain) subunit, alpha type, 2 | 3089 | 0.086 | 0.4437 | Yes |
23 | PSMB3 | PSMB3 Entrez,  Source | proteasome (prosome, macropain) subunit, beta type, 3 | 3105 | 0.085 | 0.4608 | Yes |
24 | TAP2 | TAP2 Entrez,  Source | transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) | 3296 | 0.082 | 0.4687 | Yes |
25 | TAP1 | TAP1 Entrez,  Source | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | 3389 | 0.080 | 0.4809 | Yes |
26 | UBC | UBC Entrez,  Source | ubiquitin C | 3672 | 0.074 | 0.4827 | Yes |
27 | PSMB7 | PSMB7 Entrez,  Source | proteasome (prosome, macropain) subunit, beta type, 7 | 3872 | 0.071 | 0.4877 | Yes |
28 | PSMF1 | PSMF1 Entrez,  Source | proteasome (prosome, macropain) inhibitor subunit 1 (PI31) | 4026 | 0.067 | 0.4943 | Yes |
29 | HLA-E | HLA-E Entrez,  Source | major histocompatibility complex, class I, E | 4076 | 0.066 | 0.5058 | Yes |
30 | PSMD14 | PSMD14 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 4615 | 0.057 | 0.4916 | Yes |
31 | PSME1 | PSME1 Entrez,  Source | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) | 4671 | 0.056 | 0.5007 | Yes |
32 | HLA-F | HLA-F Entrez,  Source | major histocompatibility complex, class I, F | 4698 | 0.056 | 0.5111 | Yes |
33 | PSMD9 | PSMD9 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 | 4808 | 0.054 | 0.5171 | Yes |
34 | PSMD7 | PSMD7 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog) | 5183 | 0.048 | 0.5091 | Yes |
35 | PSMD13 | PSMD13 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 | 5236 | 0.048 | 0.5165 | Yes |
36 | PSMB6 | PSMB6 Entrez,  Source | proteasome (prosome, macropain) subunit, beta type, 6 | 5421 | 0.045 | 0.5168 | Yes |
37 | PSMD3 | PSMD3 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | 5549 | 0.043 | 0.5195 | Yes |
38 | PSME4 | PSME4 Entrez,  Source | proteasome (prosome, macropain) activator subunit 4 | 5606 | 0.042 | 0.5255 | Yes |
39 | HLA-A | HLA-A Entrez,  Source | major histocompatibility complex, class I, A | 5626 | 0.042 | 0.5333 | Yes |
40 | PSMA5 | PSMA5 Entrez,  Source | proteasome (prosome, macropain) subunit, alpha type, 5 | 5723 | 0.040 | 0.5370 | Yes |
41 | HLA-G | HLA-G Entrez,  Source | HLA-G histocompatibility antigen, class I, G | 5781 | 0.039 | 0.5424 | Yes |
42 | PSMD8 | PSMD8 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 | 5824 | 0.039 | 0.5485 | Yes |
43 | PSME2 | PSME2 Entrez,  Source | proteasome (prosome, macropain) activator subunit 2 (PA28 beta) | 5861 | 0.038 | 0.5547 | Yes |
44 | PSMD6 | PSMD6 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 | 6328 | 0.032 | 0.5388 | No |
45 | PSMA7 | PSMA7 Entrez,  Source | proteasome (prosome, macropain) subunit, alpha type, 7 | 6545 | 0.029 | 0.5344 | No |
46 | PSME3 | PSME3 Entrez,  Source | proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) | 6666 | 0.028 | 0.5344 | No |
47 | PSMB4 | PSMB4 Entrez,  Source | proteasome (prosome, macropain) subunit, beta type, 4 | 7362 | 0.019 | 0.5045 | No |
48 | PSMA6 | PSMA6 Entrez,  Source | proteasome (prosome, macropain) subunit, alpha type, 6 | 7369 | 0.019 | 0.5081 | No |
49 | PSMC1 | PSMC1 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, ATPase, 1 | 7425 | 0.018 | 0.5092 | No |
50 | PSMA8 | PSMA8 Entrez,  Source | proteasome (prosome, macropain) subunit, alpha type, 8 | 7594 | 0.016 | 0.5043 | No |
51 | CALR | CALR Entrez,  Source | calreticulin | 7597 | 0.016 | 0.5075 | No |
52 | PSMD2 | PSMD2 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 7724 | 0.014 | 0.5043 | No |
53 | PSMC2 | PSMC2 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, ATPase, 2 | 7768 | 0.014 | 0.5051 | No |
54 | PSMD4 | PSMD4 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 | 7848 | 0.013 | 0.5039 | No |
55 | HLA-C | HLA-C Entrez,  Source | major histocompatibility complex, class I, C | 8160 | 0.009 | 0.4906 | No |
56 | PSMB1 | PSMB1 Entrez,  Source | proteasome (prosome, macropain) subunit, beta type, 1 | 8459 | 0.005 | 0.4771 | No |
57 | PSMD11 | PSMD11 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 8611 | 0.003 | 0.4704 | No |
58 | HLA-B | HLA-B Entrez,  Source | major histocompatibility complex, class I, B | 8731 | 0.002 | 0.4650 | No |
59 | UBA52 | UBA52 Entrez,  Source | ubiquitin A-52 residue ribosomal protein fusion product 1 | 8957 | -0.001 | 0.4542 | No |
60 | TAPBP | TAPBP Entrez,  Source | TAP binding protein (tapasin) | 9030 | -0.002 | 0.4511 | No |
61 | PSMA1 | PSMA1 Entrez,  Source | proteasome (prosome, macropain) subunit, alpha type, 1 | 9405 | -0.006 | 0.4341 | No |
62 | B2M | B2M Entrez,  Source | beta-2-microglobulin | 9578 | -0.008 | 0.4273 | No |
63 | PSMB5 | PSMB5 Entrez,  Source | proteasome (prosome, macropain) subunit, beta type, 5 | 9941 | -0.012 | 0.4121 | No |
64 | UBB | UBB Entrez,  Source | ubiquitin B | 11292 | -0.027 | 0.3520 | No |
65 | PSMC3 | PSMC3 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, ATPase, 3 | 11720 | -0.032 | 0.3378 | No |
66 | PSMD1 | PSMD1 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | 13035 | -0.046 | 0.2835 | No |
67 | PSMC5 | PSMC5 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, ATPase, 5 | 13791 | -0.054 | 0.2580 | No |
68 | RPS27A | RPS27A Entrez,  Source | ribosomal protein S27a | 14405 | -0.062 | 0.2410 | No |
69 | SEC61A1 | SEC61A1 Entrez,  Source | Sec61 alpha 1 subunit (S. cerevisiae) | 15029 | -0.069 | 0.2252 | No |
70 | ITGB5 | ITGB5 Entrez,  Source | integrin, beta 5 | 17272 | -0.101 | 0.1372 | No |
71 | CD207 | CD207 Entrez,  Source | CD207 molecule, langerin | 18298 | -0.120 | 0.1123 | No |