Datasetgse25507_collapsed_to_symbols.gse25507.gpl570.cls
#N_versus_Y.gse25507.gpl570.cls
#N_versus_Y_repos
Phenotypegse25507.gpl570.cls#N_versus_Y_repos
Upregulated in classN
GeneSetVESICLE ORGANIZATION
Enrichment Score (ES)0.44763428
Normalized Enrichment Score (NES)1.7373866
Nominal p-value0.005964215
FDR q-value1.0
FWER p-Value0.988
Table: GSEA Results Summary



Fig 1: Enrichment plot: VESICLE ORGANIZATION   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1RAB8ARAB8A
Entrez,  Source
RAB8A, member RAS oncogene family530.2540.0203Yes
2SEC24BSEC24B
Entrez,  Source
SEC24 related gene family, member B (S. cerevisiae)750.2410.0410Yes
3STXBP1STXBP1
Entrez,  Source
syntaxin binding protein 11090.2270.0598Yes
4RAB34RAB34
Entrez,  Source
RAB34, member RAS oncogene family1190.2250.0797Yes
5LYSTLYST
Entrez,  Source
lysosomal trafficking regulator3260.1930.0870Yes
6RAB1ARAB1A
Entrez,  Source
RAB1A, member RAS oncogene family3640.1890.1022Yes
7STX6STX6
Entrez,  Source
syntaxin 64050.1840.1169Yes
8COPECOPE
Entrez,  Source
coatomer protein complex, subunit epsilon4510.1800.1309Yes
9CHMP5CHMP5
Entrez,  Source
chromatin modifying protein 55080.1760.1440Yes
10CNIH3CNIH3
Entrez,  Source
cornichon homolog 3 (Drosophila)5300.1740.1586Yes
11KIF13AKIF13A
Entrez,  Source
kinesin family member 13A5740.1710.1719Yes
12F8F8
Entrez,  Source
coagulation factor VIII, procoagulant component (hemophilia A)6100.1690.1853Yes
13CHMP2BCHMP2B
Entrez,  Source
chromatin modifying protein 2B6460.1660.1986Yes
14ANKFY1ANKFY1
Entrez,  Source
ankyrin repeat and FYVE domain containing 18770.1520.2010Yes
15SNX11SNX11
Entrez,  Source
sorting nexin 1110170.1460.2073Yes
16NAPANAPA
Entrez,  Source
N-ethylmaleimide-sensitive factor attachment protein, alpha11530.1400.2133Yes
17FCHO2FCHO2
Entrez,  Source
FCH domain only 211680.1390.2251Yes
18VPS4BVPS4B
Entrez,  Source
vacuolar protein sorting 4 homolog B (S. cerevisiae)11790.1380.2371Yes
19TRAPPC1TRAPPC1
Entrez,  Source
trafficking protein particle complex 115000.1270.2329Yes
20WASLWASL
Entrez,  Source
Wiskott-Aldrich syndrome-like15260.1260.2430Yes
21BET1BET1
Entrez,  Source
BET1 homolog (S. cerevisiae)16440.1230.2483Yes
22TMED2TMED2
Entrez,  Source
transmembrane emp24 domain trafficking protein 216600.1220.2586Yes
23VPS8VPS8
Entrez,  Source
vacuolar protein sorting 8 homolog (S. cerevisiae)17610.1190.2644Yes
24EEA1EEA1
Entrez,  Source
early endosome antigen 1, 162kD17750.1180.2744Yes
25TBPL1TBPL1
Entrez,  Source
TBP-like 118550.1160.2810Yes
26VPS37AVPS37A
Entrez,  Source
vacuolar protein sorting 37 homolog A (S. cerevisiae)18850.1150.2900Yes
27AP2S1AP2S1
Entrez,  Source
adaptor-related protein complex 2, sigma 1 subunit19000.1140.2996Yes
28CTSZCTSZ
Entrez,  Source
cathepsin Z19150.1140.3092Yes
29TRAPPC6BTRAPPC6B
Entrez,  Source
trafficking protein particle complex 6B20880.1090.3106Yes
30CD59CD59
Entrez,  Source
CD59 molecule, complement regulatory protein22000.1060.3147Yes
31SEC23IPSEC23IP
Entrez,  Source
SEC23 interacting protein22360.1050.3225Yes
32SEC22BSEC22B
Entrez,  Source
SEC22 vesicle trafficking protein homolog B (S. cerevisiae)23530.1020.3260Yes
33RAB38RAB38
Entrez,  Source
RAB38, member RAS oncogene family23700.1020.3344Yes
34CHMP4CCHMP4C
Entrez,  Source
chromatin modifying protein 4C23730.1020.3435Yes
35MCFD2MCFD2
Entrez,  Source
multiple coagulation factor deficiency 223860.1020.3521Yes
36SEC23ASEC23A
Entrez,  Source
Sec23 homolog A (S. cerevisiae)25690.0970.3519Yes
37TRAPPC5TRAPPC5
Entrez,  Source
trafficking protein particle complex 525770.0970.3603Yes
38COPB2COPB2
Entrez,  Source
coatomer protein complex, subunit beta 2 (beta prime)26720.0950.3643Yes
39CHMP4BCHMP4B
Entrez,  Source
chromatin modifying protein 4B27430.0930.3693Yes
40GOLPH3GOLPH3
Entrez,  Source
golgi phosphoprotein 3 (coat-protein)28100.0920.3743Yes
41PIK3C2APIK3C2A
Entrez,  Source
phosphoinositide-3-kinase, class 2, alpha polypeptide28610.0910.3800Yes
42F5F5
Entrez,  Source
coagulation factor V (proaccelerin, labile factor)29730.0880.3825Yes
43TSG101TSG101
Entrez,  Source
tumor susceptibility gene 10132070.0840.3787Yes
44PAFAH1B1PAFAH1B1
Entrez,  Source
platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa32570.0830.3837Yes
45TGFATGFA
Entrez,  Source
transforming growth factor, alpha32590.0830.3911Yes
46CHMP2ACHMP2A
Entrez,  Source
chromatin modifying protein 2A32670.0830.3982Yes
47SEC24DSEC24D
Entrez,  Source
SEC24 related gene family, member D (S. cerevisiae)32710.0820.4055Yes
48SEC24ASEC24A
Entrez,  Source
SEC24 related gene family, member A (S. cerevisiae)32730.0820.4128Yes
49TRAPPC3TRAPPC3
Entrez,  Source
trafficking protein particle complex 333260.0810.4176Yes
50SORT1SORT1
Entrez,  Source
sortilin 134360.0790.4194Yes
51SAR1BSAR1B
Entrez,  Source
SAR1 gene homolog B (S. cerevisiae)34370.0790.4265Yes
52HIP1HIP1
Entrez,  Source
huntingtin interacting protein 135080.0780.4301Yes
53SCFD1SCFD1
Entrez,  Source
sec1 family domain containing 135530.0770.4349Yes
54TRAPPC2TRAPPC2
Entrez,  Source
trafficking protein particle complex 236630.0750.4362Yes
55RILPRILP
Entrez,  Source
Rab interacting lysosomal protein37060.0740.4408Yes
56NSFNSF
Entrez,  Source
N-ethylmaleimide-sensitive factor37190.0730.4468Yes
57COPACOPA
Entrez,  Source
coatomer protein complex, subunit alpha38350.0710.4476Yes
58CHMP6CHMP6
Entrez,  Source
chromatin modifying protein 641230.0660.4395No
59KLHL12KLHL12
Entrez,  Source
kelch-like 12 (Drosophila)42520.0630.4389No
60CORO1ACORO1A
Entrez,  Source
coronin, actin binding protein, 1A43990.0610.4373No
61ZDHHC15ZDHHC15
Entrez,  Source
zinc finger, DHHC-type containing 1545930.0580.4331No
62EPS15EPS15
Entrez,  Source
epidermal growth factor receptor pathway substrate 1548400.0540.4259No
63AP3B1AP3B1
Entrez,  Source
adaptor-related protein complex 3, beta 1 subunit50110.0510.4222No
64PICALMPICALM
Entrez,  Source
phosphatidylinositol binding clathrin assembly protein50890.0500.4229No
65SERPINA1SERPINA1
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 152090.0480.4214No
66VTI1AVTI1A
Entrez,  Source
vesicle transport through interaction with t-SNAREs homolog 1A (yeast)52390.0480.4243No
67TMED9TMED9
Entrez,  Source
transmembrane emp24 protein transport domain containing 952530.0470.4279No
68S100A10S100A10
Entrez,  Source
S100 calcium binding protein A1052730.0470.4312No
69AP1M1AP1M1
Entrez,  Source
adaptor-related protein complex 1, mu 1 subunit56100.0420.4185No
70TRAPPC6ATRAPPC6A
Entrez,  Source
trafficking protein particle complex 6A59050.0380.4076No
71TMF1TMF1
Entrez,  Source
TATA element modulatory factor 159710.0370.4077No
72CSNK1DCSNK1D
Entrez,  Source
casein kinase 1, delta60130.0360.4090No
73PDCD6IPPDCD6IP
Entrez,  Source
programmed cell death 6 interacting protein60780.0360.4091No
74RAB1BRAB1B
Entrez,  Source
RAB1B, member RAS oncogene family61030.0350.4110No
75SNX19SNX19
Entrez,  Source
sorting nexin 1962350.0330.4076No
76VPS28VPS28
Entrez,  Source
vacuolar protein sorting 28 homolog (S. cerevisiae)63420.0320.4053No
77VPS41VPS41
Entrez,  Source
vacuolar protein sorting 41 (yeast)64170.0310.4045No
78RAB20RAB20
Entrez,  Source
RAB20, member RAS oncogene family64930.0300.4036No
79CLCN3CLCN3
Entrez,  Source
chloride channel 366110.0290.4004No
80VPS37CVPS37C
Entrez,  Source
vacuolar protein sorting 37 homolog C (S. cerevisiae)67560.0270.3958No
81CAV2CAV2
Entrez,  Source
caveolin 267810.0260.3970No
82PVRL2PVRL2
Entrez,  Source
poliovirus receptor-related 2 (herpesvirus entry mediator B)69010.0250.3934No
83COPB1COPB1
Entrez,  Source
coatomer protein complex, subunit beta 169660.0240.3924No
84LRSAM1LRSAM1
Entrez,  Source
leucine rich repeat and sterile alpha motif containing 171090.0220.3874No
85SNX3SNX3
Entrez,  Source
sorting nexin 371580.0210.3870No
86CHMP1BCHMP1B
Entrez,  Source
chromatin modifying protein 1B72210.0210.3858No
87ZPBP2ZPBP2
Entrez,  Source
zona pellucida binding protein 273630.0190.3806No
88TFGTFG
Entrez,  Source
TRK-fused gene73920.0180.3809No
89TRAPPC2LTRAPPC2L
Entrez,  Source
trafficking protein particle complex 2-like77470.0140.3649No
90FOLR1FOLR1
Entrez,  Source
folate receptor 1 (adult)78560.0130.3608No
91NKD2NKD2
Entrez,  Source
naked cuticle homolog 2 (Drosophila)81120.0090.3491No
92TGFBRAP1TGFBRAP1
Entrez,  Source
transforming growth factor, beta receptor associated protein 181310.0090.3490No
93VAPAVAPA
Entrez,  Source
VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa81660.0080.3481No
94TRAPPC4TRAPPC4
Entrez,  Source
trafficking protein particle complex 481800.0080.3483No
95SHROOM2SHROOM2
Entrez,  Source
shroom family member 283410.0060.3410No
96SEC31ASEC31A
Entrez,  Source
SEC31 homolog A (S. cerevisiae)86310.0030.3272No
97AREGAREG
Entrez,  Source
amphiregulin (schwannoma-derived growth factor)87060.0020.3237No
98DLG4DLG4
Entrez,  Source
discs, large homolog 4 (Drosophila)9121-0.0030.3037No
99GOLGA2GOLGA2
Entrez,  Source
golgi autoantigen, golgin subfamily a, 29199-0.0040.3003No
100VAPBVAPB
Entrez,  Source
VAMP (vesicle-associated membrane protein)-associated protein B and C9204-0.0040.3004No
101ARF1ARF1
Entrez,  Source
ADP-ribosylation factor 19245-0.0040.2989No
102FNBP1LFNBP1L
Entrez,  Source
formin binding protein 1-like9410-0.0060.2914No
103VPS37BVPS37B
Entrez,  Source
vacuolar protein sorting 37 homolog B (S. cerevisiae)9569-0.0080.2843No
104FCHO1FCHO1
Entrez,  Source
FCH domain only 19652-0.0080.2811No
105TMED10TMED10
Entrez,  Source
transmembrane emp24-like trafficking protein 10 (yeast)9658-0.0090.2816No
106PPP6CPPP6C
Entrez,  Source
protein phosphatase 6, catalytic subunit9978-0.0120.2671No
107LMAN1LMAN1
Entrez,  Source
lectin, mannose-binding, 110286-0.0150.2535No
108ANKRD28ANKRD28
Entrez,  Source
ankyrin repeat domain 2810295-0.0160.2545No
109ABCA1ABCA1
Entrez,  Source
ATP-binding cassette, sub-family A (ABC1), member 110391-0.0160.2513No
110ARCN1ARCN1
Entrez,  Source
archain 110472-0.0180.2490No
111CUL3CUL3
Entrez,  Source
cullin 310774-0.0210.2362No
112LRMPLRMP
Entrez,  Source
lymphoid-restricted membrane protein10902-0.0230.2320No
113RAB32RAB32
Entrez,  Source
RAB32, member RAS oncogene family10908-0.0230.2338No
114GORASP1GORASP1
Entrez,  Source
golgi reassembly stacking protein 1, 65kDa11260-0.0260.2190No
115SPACA1SPACA1
Entrez,  Source
sperm acrosome associated 111271-0.0260.2209No
116ANXA2ANXA2
Entrez,  Source
annexin A211386-0.0280.2179No
117GBF1GBF1
Entrez,  Source
golgi-specific brefeldin A resistance factor 111953-0.0340.1933No
118VPS4AVPS4A
Entrez,  Source
vacuolar protein sorting 4 homolog A (S. cerevisiae)12218-0.0370.1838No
119PLA2G3PLA2G3
Entrez,  Source
phospholipase A2, group III12599-0.0410.1689No
120CNIH2CNIH2
Entrez,  Source
cornichon homolog 2 (Drosophila)12922-0.0450.1572No
121VPS39VPS39
Entrez,  Source
vacuolar protein sorting 39 (yeast)13059-0.0460.1547No
122COPZ1COPZ1
Entrez,  Source
coatomer protein complex, subunit zeta 113522-0.0510.1368No
123CHMP4ACHMP4A
Entrez,  Source
chromatin modifying protein 4A13561-0.0520.1396No
124RAB3ARAB3A
Entrez,  Source
RAB3A, member RAS oncogene family13812-0.0550.1323No
125VPS11VPS11
Entrez,  Source
vacuolar protein sorting 11 (yeast)13846-0.0550.1356No
126UNC13AUNC13A
Entrez,  Source
unc-13 homolog A (C. elegans)14212-0.0590.1231No
127TBC1D20TBC1D20
Entrez,  Source
TBC1 domain family, member 2014663-0.0650.1069No
128VPS33BVPS33B
Entrez,  Source
vacuolar protein sorting 33B (yeast)15226-0.0720.0859No
129CTSCCTSC
Entrez,  Source
cathepsin C15317-0.0730.0881No
130ZPBPZPBP
Entrez,  Source
zona pellucida binding protein15337-0.0730.0937No
131COL7A1COL7A1
Entrez,  Source
collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive)15720-0.0780.0821No
132PTPRNPTPRN
Entrez,  Source
protein tyrosine phosphatase, receptor type, N16337-0.0870.0599No
133GPR143GPR143
Entrez,  Source
G protein-coupled receptor 14316600-0.0910.0552No
134GOSR2GOSR2
Entrez,  Source
golgi SNAP receptor complex member 216666-0.0920.0604No
135GRIA1GRIA1
Entrez,  Source
glutamate receptor, ionotropic, AMPA 116920-0.0960.0566No
136CAV1CAV1
Entrez,  Source
caveolin 1, caveolae protein, 22kDa17047-0.0980.0593No
137CD34CD34
Entrez,  Source
CD34 molecule17176-0.1000.0620No
138SEC24CSEC24C
Entrez,  Source
SEC24 related gene family, member C (S. cerevisiae)17684-0.1080.0470No
139PREBPREB
Entrez,  Source
prolactin regulatory element binding17766-0.1100.0529No
140VAMP4VAMP4
Entrez,  Source
vesicle-associated membrane protein 417900-0.1120.0565No
141STX5STX5
Entrez,  Source
syntaxin 518695-0.1290.0293No
142ARFGAP1ARFGAP1
Entrez,  Source
ADP-ribosylation factor GTPase activating protein 119414-0.1490.0077No
143SLC17A7SLC17A7
Entrez,  Source
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 719744-0.1630.0063No
144VPS37DVPS37D
Entrez,  Source
vacuolar protein sorting 37 homolog D (S. cerevisiae)20250-0.198-0.0006No
145PLEKHF1PLEKHF1
Entrez,  Source
pleckstrin homology domain containing, family F (with FYVE domain) member 120255-0.1990.0171No
Table: GSEA details [plain text format]



Fig 2: VESICLE ORGANIZATION   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: VESICLE ORGANIZATION: Random ES distribution   
Gene set null distribution of ES for VESICLE ORGANIZATION