Datasetgse25507_collapsed_to_symbols.gse25507.gpl570.cls
#N_versus_Y.gse25507.gpl570.cls
#N_versus_Y_repos
Phenotypegse25507.gpl570.cls#N_versus_Y_repos
Upregulated in classN
GeneSetANTIGEN PROCESSING AND PRESENTATION OF EXOGENOUS PEPTIDE ANTIGEN VIA MHC CLASS I
Enrichment Score (ES)0.5656557
Normalized Enrichment Score (NES)1.7413354
Nominal p-value0.025052192
FDR q-value1.0
FWER p-Value0.985
Table: GSEA Results Summary



Fig 1: Enrichment plot: ANTIGEN PROCESSING AND PRESENTATION OF EXOGENOUS PEPTIDE ANTIGEN VIA MHC CLASS I   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1CYBBCYBB
Entrez,  Source
cytochrome b-245, beta polypeptide (chronic granulomatous disease)970.2300.0401Yes
2PSMB9PSMB9
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)2940.1970.0689Yes
3CYBACYBA
Entrez,  Source
cytochrome b-245, alpha polypeptide5220.1750.0919Yes
4CD36CD36
Entrez,  Source
CD36 molecule (thrombospondin receptor)5430.1730.1246Yes
5FCGR1AFCGR1A
Entrez,  Source
Fc fragment of IgG, high affinity Ia, receptor (CD64)7190.1600.1474Yes
6PDIA3PDIA3
Entrez,  Source
protein disulfide isomerase family A, member 39630.1480.1644Yes
7CTSSCTSS
Entrez,  Source
cathepsin S12570.1350.1764Yes
8SEC61GSEC61G
Entrez,  Source
Sec61 gamma subunit12830.1340.2014Yes
9PSMC6PSMC6
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, ATPase, 612880.1340.2273Yes
10SEC61A2SEC61A2
Entrez,  Source
Sec61 alpha 2 subunit (S. cerevisiae)13660.1310.2491Yes
11PSMA3PSMA3
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 314130.1300.2722Yes
12PSMD12PSMD12
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1215100.1270.2922Yes
13NCF4NCF4
Entrez,  Source
neutrophil cytosolic factor 4, 40kDa16360.1230.3100Yes
14PSMD10PSMD10
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1017600.1190.3272Yes
15ITGAVITGAV
Entrez,  Source
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)18420.1160.3459Yes
16IFI30IFI30
Entrez,  Source
interferon, gamma-inducible protein 3019650.1130.3620Yes
17PSMB2PSMB2
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 221390.1080.3745Yes
18PSMA4PSMA4
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 425110.0990.3757Yes
19PSMB10PSMB10
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 1026490.0950.3876Yes
20LNPEPLNPEP
Entrez,  Source
leucyl/cystinyl aminopeptidase26790.0950.4047Yes
21NCF2NCF2
Entrez,  Source
neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2)27730.0930.4182Yes
22PSMB8PSMB8
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)29210.0890.4284Yes
23SEC61BSEC61B
Entrez,  Source
Sec61 beta subunit30230.0870.4405Yes
24PSMD5PSMD5
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 530300.0870.4571Yes
25PSMA2PSMA2
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 230890.0860.4710Yes
26PSMB3PSMB3
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 331050.0850.4869Yes
27TAP2TAP2
Entrez,  Source
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)32960.0820.4936Yes
28TAP1TAP1
Entrez,  Source
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)33890.0800.5047Yes
29UBCUBC
Entrez,  Source
ubiquitin C36720.0740.5055Yes
30PSMB7PSMB7
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 738720.0710.5095Yes
31PSMF1PSMF1
Entrez,  Source
proteasome (prosome, macropain) inhibitor subunit 1 (PI31)40260.0670.5152Yes
32HLA-EHLA-E
Entrez,  Source
major histocompatibility complex, class I, E40760.0660.5258Yes
33PSMD14PSMD14
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1446150.0570.5107Yes
34PSME1PSME1
Entrez,  Source
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)46710.0560.5191Yes
35HLA-FHLA-F
Entrez,  Source
major histocompatibility complex, class I, F46980.0560.5287Yes
36PSMD9PSMD9
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 948080.0540.5340Yes
37PSMD7PSMD7
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog)51830.0480.5252Yes
38PSMD13PSMD13
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1352360.0480.5319Yes
39PSMB6PSMB6
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 654210.0450.5317Yes
40PSMD3PSMD3
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 355490.0430.5338Yes
41PSME4PSME4
Entrez,  Source
proteasome (prosome, macropain) activator subunit 456060.0420.5392Yes
42HLA-AHLA-A
Entrez,  Source
major histocompatibility complex, class I, A56260.0420.5464Yes
43PSMA5PSMA5
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 557230.0400.5495Yes
44HLA-GHLA-G
Entrez,  Source
HLA-G histocompatibility antigen, class I, G57810.0390.5544Yes
45PSMD8PSMD8
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 858240.0390.5599Yes
46PSME2PSME2
Entrez,  Source
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)58610.0380.5657Yes
47PSMD6PSMD6
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 663280.0320.5492No
48PSMA7PSMA7
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 765450.0290.5444No
49PSME3PSME3
Entrez,  Source
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)66660.0280.5440No
50PSMB4PSMB4
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 473620.0190.5139No
51PSMA6PSMA6
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 673690.0190.5172No
52PSMC1PSMC1
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, ATPase, 174250.0180.5180No
53PSMA8PSMA8
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 875940.0160.5129No
54CALRCALR
Entrez,  Source
calreticulin75970.0160.5159No
55PSMD2PSMD2
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 277240.0140.5126No
56PSMC2PSMC2
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, ATPase, 277680.0140.5132No
57PSMD4PSMD4
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 478480.0130.5118No
58HLA-CHLA-C
Entrez,  Source
major histocompatibility complex, class I, C81600.0090.4983No
59PSMB1PSMB1
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 184590.0050.4848No
60PSMD11PSMD11
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1186110.0030.4781No
61HLA-BHLA-B
Entrez,  Source
major histocompatibility complex, class I, B87310.0020.4726No
62UBA52UBA52
Entrez,  Source
ubiquitin A-52 residue ribosomal protein fusion product 18957-0.0010.4618No
63TAPBPTAPBP
Entrez,  Source
TAP binding protein (tapasin)9030-0.0020.4587No
64PSMA1PSMA1
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 19405-0.0060.4416No
65B2MB2M
Entrez,  Source
beta-2-microglobulin9578-0.0080.4347No
66PSMB5PSMB5
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 59941-0.0120.4193No
67UBBUBB
Entrez,  Source
ubiquitin B11292-0.0270.3588No
68PSMC3PSMC3
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, ATPase, 311720-0.0320.3442No
69PSMD1PSMD1
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 113035-0.0460.2892No
70PSMC5PSMC5
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, ATPase, 513791-0.0540.2630No
71RPS27ARPS27A
Entrez,  Source
ribosomal protein S27a14405-0.0620.2451No
72SEC61A1SEC61A1
Entrez,  Source
Sec61 alpha 1 subunit (S. cerevisiae)15029-0.0690.2283No
73ITGB5ITGB5
Entrez,  Source
integrin, beta 517272-0.1010.1389No
74CD207CD207
Entrez,  Source
CD207 molecule, langerin18298-0.1200.1124No
Table: GSEA details [plain text format]



Fig 2: ANTIGEN PROCESSING AND PRESENTATION OF EXOGENOUS PEPTIDE ANTIGEN VIA MHC CLASS I   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: ANTIGEN PROCESSING AND PRESENTATION OF EXOGENOUS PEPTIDE ANTIGEN VIA MHC CLASS I: Random ES distribution   
Gene set null distribution of ES for ANTIGEN PROCESSING AND PRESENTATION OF EXOGENOUS PEPTIDE ANTIGEN VIA MHC CLASS I