Dataset | gse25507_collapsed_to_symbols.gse25507.gpl570.cls #N_versus_Y.gse25507.gpl570.cls #N_versus_Y_repos |
Phenotype | gse25507.gpl570.cls#N_versus_Y_repos |
Upregulated in class | N |
GeneSet | ANTIGEN PROCESSING AND PRESENTATION OF PEPTIDE ANTIGEN VIA MHC CLASS I |
Enrichment Score (ES) | 0.5381526 |
Normalized Enrichment Score (NES) | 1.7173059 |
Nominal p-value | 0.033613447 |
FDR q-value | 1.0 |
FWER p-Value | 0.995 |
PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
---|---|---|---|---|---|---|---|
1 | SEC24B | SEC24B Entrez,  Source | SEC24 related gene family, member B (S. cerevisiae) | 75 | 0.241 | 0.0359 | Yes |
2 | CYBB | CYBB Entrez,  Source | cytochrome b-245, beta polypeptide (chronic granulomatous disease) | 97 | 0.230 | 0.0727 | Yes |
3 | PSMB9 | PSMB9 Entrez,  Source | proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) | 294 | 0.197 | 0.0955 | Yes |
4 | CYBA | CYBA Entrez,  Source | cytochrome b-245, alpha polypeptide | 522 | 0.175 | 0.1131 | Yes |
5 | CD36 | CD36 Entrez,  Source | CD36 molecule (thrombospondin receptor) | 543 | 0.173 | 0.1405 | Yes |
6 | FCGR1A | FCGR1A Entrez,  Source | Fc fragment of IgG, high affinity Ia, receptor (CD64) | 719 | 0.160 | 0.1583 | Yes |
7 | PDIA3 | PDIA3 Entrez,  Source | protein disulfide isomerase family A, member 3 | 963 | 0.148 | 0.1708 | Yes |
8 | CTSS | CTSS Entrez,  Source | cathepsin S | 1257 | 0.135 | 0.1787 | Yes |
9 | SEC61G | SEC61G Entrez,  Source | Sec61 gamma subunit | 1283 | 0.134 | 0.1995 | Yes |
10 | PSMC6 | PSMC6 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, ATPase, 6 | 1288 | 0.134 | 0.2213 | Yes |
11 | SEC61A2 | SEC61A2 Entrez,  Source | Sec61 alpha 2 subunit (S. cerevisiae) | 1366 | 0.131 | 0.2391 | Yes |
12 | PSMA3 | PSMA3 Entrez,  Source | proteasome (prosome, macropain) subunit, alpha type, 3 | 1413 | 0.130 | 0.2582 | Yes |
13 | PSMD12 | PSMD12 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 | 1510 | 0.127 | 0.2743 | Yes |
14 | NCF4 | NCF4 Entrez,  Source | neutrophil cytosolic factor 4, 40kDa | 1636 | 0.123 | 0.2883 | Yes |
15 | PSMD10 | PSMD10 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 | 1760 | 0.119 | 0.3018 | Yes |
16 | ITGAV | ITGAV Entrez,  Source | integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) | 1842 | 0.116 | 0.3170 | Yes |
17 | IFI30 | IFI30 Entrez,  Source | interferon, gamma-inducible protein 30 | 1965 | 0.113 | 0.3295 | Yes |
18 | PSMB2 | PSMB2 Entrez,  Source | proteasome (prosome, macropain) subunit, beta type, 2 | 2139 | 0.108 | 0.3388 | Yes |
19 | PSMA4 | PSMA4 Entrez,  Source | proteasome (prosome, macropain) subunit, alpha type, 4 | 2511 | 0.099 | 0.3369 | Yes |
20 | SEC23A | SEC23A Entrez,  Source | Sec23 homolog A (S. cerevisiae) | 2569 | 0.097 | 0.3501 | Yes |
21 | PSMB10 | PSMB10 Entrez,  Source | proteasome (prosome, macropain) subunit, beta type, 10 | 2649 | 0.095 | 0.3619 | Yes |
22 | LNPEP | LNPEP Entrez,  Source | leucyl/cystinyl aminopeptidase | 2679 | 0.095 | 0.3761 | Yes |
23 | NCF2 | NCF2 Entrez,  Source | neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2) | 2773 | 0.093 | 0.3867 | Yes |
24 | PSMB8 | PSMB8 Entrez,  Source | proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) | 2921 | 0.089 | 0.3942 | Yes |
25 | SEC61B | SEC61B Entrez,  Source | Sec61 beta subunit | 3023 | 0.087 | 0.4036 | Yes |
26 | PSMD5 | PSMD5 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 | 3030 | 0.087 | 0.4176 | Yes |
27 | PSMA2 | PSMA2 Entrez,  Source | proteasome (prosome, macropain) subunit, alpha type, 2 | 3089 | 0.086 | 0.4288 | Yes |
28 | PSMB3 | PSMB3 Entrez,  Source | proteasome (prosome, macropain) subunit, beta type, 3 | 3105 | 0.085 | 0.4421 | Yes |
29 | SEC24D | SEC24D Entrez,  Source | SEC24 related gene family, member D (S. cerevisiae) | 3271 | 0.082 | 0.4476 | Yes |
30 | SEC24A | SEC24A Entrez,  Source | SEC24 related gene family, member A (S. cerevisiae) | 3273 | 0.082 | 0.4611 | Yes |
31 | TAP2 | TAP2 Entrez,  Source | transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) | 3296 | 0.082 | 0.4735 | Yes |
32 | TAP1 | TAP1 Entrez,  Source | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | 3389 | 0.080 | 0.4821 | Yes |
33 | SAR1B | SAR1B Entrez,  Source | SAR1 gene homolog B (S. cerevisiae) | 3437 | 0.079 | 0.4928 | Yes |
34 | UBC | UBC Entrez,  Source | ubiquitin C | 3672 | 0.074 | 0.4936 | Yes |
35 | PSMB7 | PSMB7 Entrez,  Source | proteasome (prosome, macropain) subunit, beta type, 7 | 3872 | 0.071 | 0.4955 | Yes |
36 | PSMF1 | PSMF1 Entrez,  Source | proteasome (prosome, macropain) inhibitor subunit 1 (PI31) | 4026 | 0.067 | 0.4991 | Yes |
37 | HLA-E | HLA-E Entrez,  Source | major histocompatibility complex, class I, E | 4076 | 0.066 | 0.5076 | Yes |
38 | UBE2A | UBE2A Entrez,  Source | ubiquitin-conjugating enzyme E2A (RAD6 homolog) | 4183 | 0.064 | 0.5130 | Yes |
39 | PSMD14 | PSMD14 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 4615 | 0.057 | 0.5014 | Yes |
40 | PSME1 | PSME1 Entrez,  Source | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) | 4671 | 0.056 | 0.5080 | Yes |
41 | HLA-F | HLA-F Entrez,  Source | major histocompatibility complex, class I, F | 4698 | 0.056 | 0.5159 | Yes |
42 | PSMD9 | PSMD9 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 | 4808 | 0.054 | 0.5195 | Yes |
43 | PSMD7 | PSMD7 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog) | 5183 | 0.048 | 0.5092 | Yes |
44 | PSMD13 | PSMD13 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 | 5236 | 0.048 | 0.5145 | Yes |
45 | PSMB6 | PSMB6 Entrez,  Source | proteasome (prosome, macropain) subunit, beta type, 6 | 5421 | 0.045 | 0.5129 | Yes |
46 | PSMD3 | PSMD3 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | 5549 | 0.043 | 0.5137 | Yes |
47 | PSME4 | PSME4 Entrez,  Source | proteasome (prosome, macropain) activator subunit 4 | 5606 | 0.042 | 0.5178 | Yes |
48 | HLA-A | HLA-A Entrez,  Source | major histocompatibility complex, class I, A | 5626 | 0.042 | 0.5237 | Yes |
49 | PSMA5 | PSMA5 Entrez,  Source | proteasome (prosome, macropain) subunit, alpha type, 5 | 5723 | 0.040 | 0.5256 | Yes |
50 | HLA-G | HLA-G Entrez,  Source | HLA-G histocompatibility antigen, class I, G | 5781 | 0.039 | 0.5293 | Yes |
51 | PSMD8 | PSMD8 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 | 5824 | 0.039 | 0.5336 | Yes |
52 | PSME2 | PSME2 Entrez,  Source | proteasome (prosome, macropain) activator subunit 2 (PA28 beta) | 5861 | 0.038 | 0.5382 | Yes |
53 | PSMD6 | PSMD6 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 | 6328 | 0.032 | 0.5207 | No |
54 | PSMA7 | PSMA7 Entrez,  Source | proteasome (prosome, macropain) subunit, alpha type, 7 | 6545 | 0.029 | 0.5150 | No |
55 | PSME3 | PSME3 Entrez,  Source | proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) | 6666 | 0.028 | 0.5138 | No |
56 | PSMB4 | PSMB4 Entrez,  Source | proteasome (prosome, macropain) subunit, beta type, 4 | 7362 | 0.019 | 0.4830 | No |
57 | PSMA6 | PSMA6 Entrez,  Source | proteasome (prosome, macropain) subunit, alpha type, 6 | 7369 | 0.019 | 0.4858 | No |
58 | TPP2 | TPP2 Entrez,  Source | tripeptidyl peptidase II | 7381 | 0.019 | 0.4883 | No |
59 | PSMC1 | PSMC1 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, ATPase, 1 | 7425 | 0.018 | 0.4891 | No |
60 | PSMA8 | PSMA8 Entrez,  Source | proteasome (prosome, macropain) subunit, alpha type, 8 | 7594 | 0.016 | 0.4835 | No |
61 | CALR | CALR Entrez,  Source | calreticulin | 7597 | 0.016 | 0.4860 | No |
62 | PSMD2 | PSMD2 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 7724 | 0.014 | 0.4822 | No |
63 | PSMC2 | PSMC2 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, ATPase, 2 | 7768 | 0.014 | 0.4824 | No |
64 | PSMD4 | PSMD4 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 | 7848 | 0.013 | 0.4807 | No |
65 | HLA-C | HLA-C Entrez,  Source | major histocompatibility complex, class I, C | 8160 | 0.009 | 0.4669 | No |
66 | BCAP31 | BCAP31 Entrez,  Source | B-cell receptor-associated protein 31 | 8182 | 0.008 | 0.4673 | No |
67 | PSMB1 | PSMB1 Entrez,  Source | proteasome (prosome, macropain) subunit, beta type, 1 | 8459 | 0.005 | 0.4546 | No |
68 | PSMD11 | PSMD11 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 8611 | 0.003 | 0.4478 | No |
69 | SEC31A | SEC31A Entrez,  Source | SEC31 homolog A (S. cerevisiae) | 8631 | 0.003 | 0.4473 | No |
70 | HLA-B | HLA-B Entrez,  Source | major histocompatibility complex, class I, B | 8731 | 0.002 | 0.4428 | No |
71 | UBA52 | UBA52 Entrez,  Source | ubiquitin A-52 residue ribosomal protein fusion product 1 | 8957 | -0.001 | 0.4320 | No |
72 | TAPBP | TAPBP Entrez,  Source | TAP binding protein (tapasin) | 9030 | -0.002 | 0.4288 | No |
73 | PSMA1 | PSMA1 Entrez,  Source | proteasome (prosome, macropain) subunit, alpha type, 1 | 9405 | -0.006 | 0.4115 | No |
74 | CANX | CANX Entrez,  Source | calnexin | 9528 | -0.007 | 0.4067 | No |
75 | BLMH | BLMH Entrez,  Source | bleomycin hydrolase | 9547 | -0.007 | 0.4071 | No |
76 | B2M | B2M Entrez,  Source | beta-2-microglobulin | 9578 | -0.008 | 0.4069 | No |
77 | PSMB5 | PSMB5 Entrez,  Source | proteasome (prosome, macropain) subunit, beta type, 5 | 9941 | -0.012 | 0.3911 | No |
78 | NPEPPS | NPEPPS Entrez,  Source | aminopeptidase puromycin sensitive | 10733 | -0.021 | 0.3560 | No |
79 | UBB | UBB Entrez,  Source | ubiquitin B | 11292 | -0.027 | 0.3332 | No |
80 | PSMC3 | PSMC3 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, ATPase, 3 | 11720 | -0.032 | 0.3176 | No |
81 | PSMD1 | PSMD1 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | 13035 | -0.046 | 0.2611 | No |
82 | PSMC5 | PSMC5 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, ATPase, 5 | 13791 | -0.054 | 0.2332 | No |
83 | RPS27A | RPS27A Entrez,  Source | ribosomal protein S27a | 14405 | -0.062 | 0.2135 | No |
84 | SEC61A1 | SEC61A1 Entrez,  Source | Sec61 alpha 1 subunit (S. cerevisiae) | 15029 | -0.069 | 0.1945 | No |
85 | ITGB5 | ITGB5 Entrez,  Source | integrin, beta 5 | 17272 | -0.101 | 0.1018 | No |
86 | SEC24C | SEC24C Entrez,  Source | SEC24 related gene family, member C (S. cerevisiae) | 17684 | -0.108 | 0.0996 | No |
87 | CD207 | CD207 Entrez,  Source | CD207 molecule, langerin | 18298 | -0.120 | 0.0894 | No |
88 | ACE | ACE Entrez,  Source | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | 19128 | -0.140 | 0.0720 | No |