Datasetgse25507_collapsed_to_symbols.gse25507.gpl570.cls
#N_versus_Y.gse25507.gpl570.cls
#N_versus_Y_repos
Phenotypegse25507.gpl570.cls#N_versus_Y_repos
Upregulated in classY
GeneSetPOSITIVE REGULATION OF CYCLIC NUCLEOTIDE BIOSYNTHETIC PROCESS
Enrichment Score (ES)-0.54234666
Normalized Enrichment Score (NES)-1.8632512
Nominal p-value0.002020202
FDR q-value0.5628683
FWER p-Value0.768
Table: GSEA Results Summary



Fig 1: Enrichment plot: POSITIVE REGULATION OF CYCLIC NUCLEOTIDE BIOSYNTHETIC PROCESS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1ADRB1ADRB1
Entrez,  Source
adrenergic, beta-1-, receptor20070.112-0.0742No
2ADMADM
Entrez,  Source
adrenomedullin38650.071-0.1497No
3CAP1CAP1
Entrez,  Source
CAP, adenylate cyclase-associated protein 1 (yeast)48300.054-0.1853No
4PRKCAPRKCA
Entrez,  Source
protein kinase C, alpha53950.045-0.2032No
5PTHLHPTHLH
Entrez,  Source
parathyroid hormone-like hormone60120.036-0.2256No
6MRAPMRAP
Entrez,  Source
melanocortin 2 receptor accessory protein65860.029-0.2474No
7VIPVIP
Entrez,  Source
vasoactive intestinal peptide69320.024-0.2591No
8EDNRAEDNRA
Entrez,  Source
endothelin receptor type A85320.004-0.3360No
9NOS3NOS3
Entrez,  Source
nitric oxide synthase 3 (endothelial cell)87390.002-0.3457No
10GHRHGHRH
Entrez,  Source
growth hormone releasing hormone87670.001-0.3468No
11GNASGNAS
Entrez,  Source
GNAS complex locus8949-0.001-0.3554No
12AKAP5AKAP5
Entrez,  Source
A kinase (PRKA) anchor protein 59150-0.003-0.3645No
13NF1NF1
Entrez,  Source
neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease)10093-0.013-0.4075No
14GHRHRGHRHR
Entrez,  Source
growth hormone releasing hormone receptor10094-0.013-0.4047No
15GPR161GPR161
Entrez,  Source
G protein-coupled receptor 16110321-0.016-0.4124No
16ABCA1ABCA1
Entrez,  Source
ATP-binding cassette, sub-family A (ABC1), member 110391-0.016-0.4122No
17NTRK2NTRK2
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 210742-0.021-0.4249No
18MC3RMC3R
Entrez,  Source
melanocortin 3 receptor10972-0.023-0.4312No
19CALCRLCALCRL
Entrez,  Source
calcitonin receptor-like11061-0.024-0.4303No
20MC2RMC2R
Entrez,  Source
melanocortin 2 receptor (adrenocorticotropic hormone)11454-0.029-0.4434No
21APOEAPOE
Entrez,  Source
apolipoprotein E11705-0.032-0.4489No
22ADORA2AADORA2A
Entrez,  Source
adenosine A2a receptor12918-0.045-0.4984No
23DRD1DRD1
Entrez,  Source
dopamine receptor D112921-0.045-0.4890No
24PTHPTH
Entrez,  Source
parathyroid hormone13052-0.046-0.4856No
25MC4RMC4R
Entrez,  Source
melanocortin 4 receptor13543-0.052-0.4986No
26MTNR1AMTNR1A
Entrez,  Source
melatonin receptor 1A13759-0.054-0.4978No
27GLP1RGLP1R
Entrez,  Source
glucagon-like peptide 1 receptor14676-0.065-0.5287Yes
28ADCYAP1ADCYAP1
Entrez,  Source
adenylate cyclase activating polypeptide 1 (pituitary)14782-0.066-0.5199Yes
29DRD5DRD5
Entrez,  Source
dopamine receptor D515191-0.071-0.5248Yes
30RAMP1RAMP1
Entrez,  Source
receptor (calcitonin) activity modifying protein 115356-0.073-0.5174Yes
31GPR65GPR65
Entrez,  Source
G protein-coupled receptor 6515423-0.074-0.5050Yes
32RLN2RLN2
Entrez,  Source
relaxin 215984-0.082-0.5150Yes
33GUCA1AGUCA1A
Entrez,  Source
guanylate cyclase activator 1A (retina)16032-0.083-0.4998Yes
34ADCY7ADCY7
Entrez,  Source
adenylate cyclase 716200-0.085-0.4900Yes
35RCVRNRCVRN
Entrez,  Source
recoverin16460-0.089-0.4839Yes
36GUCA1CGUCA1C
Entrez,  Source
guanylate cyclase activator 1C16462-0.089-0.4653Yes
37LHCGRLHCGR
Entrez,  Source
luteinizing hormone/choriogonadotropin receptor16890-0.095-0.4660Yes
38CALCRCALCR
Entrez,  Source
calcitonin receptor17044-0.098-0.4529Yes
39ADRB3ADRB3
Entrez,  Source
adrenergic, beta-3-, receptor17471-0.105-0.4516Yes
40MC5RMC5R
Entrez,  Source
melanocortin 5 receptor17496-0.105-0.4307Yes
41GSK3AGSK3A
Entrez,  Source
glycogen synthase kinase 3 alpha17985-0.114-0.4305Yes
42ADRB2ADRB2
Entrez,  Source
adrenergic, beta-2-, receptor, surface18267-0.119-0.4191Yes
43CAP2CAP2
Entrez,  Source
CAP, adenylate cyclase-associated protein, 2 (yeast)18305-0.120-0.3956Yes
44ADORA2BADORA2B
Entrez,  Source
adenosine A2b receptor18534-0.125-0.3803Yes
45ADCYAP1R1ADCYAP1R1
Entrez,  Source
adenylate cyclase activating polypeptide 1 (pituitary) receptor type I18920-0.134-0.3708Yes
46RAMP2RAMP2
Entrez,  Source
receptor (calcitonin) activity modifying protein 219194-0.142-0.3542Yes
47AVPR2AVPR2
Entrez,  Source
arginine vasopressin receptor 2 (nephrogenic diabetes insipidus)19482-0.152-0.3361Yes
48GUCA2BGUCA2B
Entrez,  Source
guanylate cyclase activator 2B (uroguanylin)19573-0.156-0.3077Yes
49ACRACR
Entrez,  Source
acrosin19701-0.161-0.2800Yes
50CRHR1CRHR1
Entrez,  Source
corticotropin releasing hormone receptor 119792-0.165-0.2496Yes
51PTGIRPTGIR
Entrez,  Source
prostaglandin I2 (prostacyclin) receptor (IP)19815-0.167-0.2157Yes
52CALCACALCA
Entrez,  Source
calcitonin/calcitonin-related polypeptide, alpha19817-0.167-0.1806Yes
53GIPRGIPR
Entrez,  Source
gastric inhibitory polypeptide receptor19823-0.167-0.1457Yes
54AKAP12AKAP12
Entrez,  Source
A kinase (PRKA) anchor protein (gravin) 1219949-0.174-0.1152Yes
55NTRK1NTRK1
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 120338-0.211-0.0897Yes
56P2RY11P2RY11
Entrez,  Source
purinergic receptor P2Y, G-protein coupled, 1120500-0.239-0.0473Yes
57MC1RMC1R
Entrez,  Source
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)20536-0.2490.0034Yes
Table: GSEA details [plain text format]



Fig 2: POSITIVE REGULATION OF CYCLIC NUCLEOTIDE BIOSYNTHETIC PROCESS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: POSITIVE REGULATION OF CYCLIC NUCLEOTIDE BIOSYNTHETIC PROCESS: Random ES distribution   
Gene set null distribution of ES for POSITIVE REGULATION OF CYCLIC NUCLEOTIDE BIOSYNTHETIC PROCESS