Datasetgse25507_collapsed_to_symbols.gse25507.gpl570.cls
#N_versus_Y.gse25507.gpl570.cls
#N_versus_Y_repos
Phenotypegse25507.gpl570.cls#N_versus_Y_repos
Upregulated in classN
GeneSetMEMBRANE BUDDING
Enrichment Score (ES)0.5003292
Normalized Enrichment Score (NES)1.7548982
Nominal p-value0.0
FDR q-value1.0
FWER p-Value0.979
Table: GSEA Results Summary



Fig 1: Enrichment plot: MEMBRANE BUDDING   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1SEC24BSEC24B
Entrez,  Source
SEC24 related gene family, member B (S. cerevisiae)750.2410.0304Yes
2RAB1ARAB1A
Entrez,  Source
RAB1A, member RAS oncogene family3640.1890.0431Yes
3COPECOPE
Entrez,  Source
coatomer protein complex, subunit epsilon4510.1800.0642Yes
4CHMP5CHMP5
Entrez,  Source
chromatin modifying protein 55080.1760.0863Yes
5CNIH3CNIH3
Entrez,  Source
cornichon homolog 3 (Drosophila)5300.1740.1099Yes
6F8F8
Entrez,  Source
coagulation factor VIII, procoagulant component (hemophilia A)6100.1690.1298Yes
7CHMP2BCHMP2B
Entrez,  Source
chromatin modifying protein 2B6460.1660.1515Yes
8NAPANAPA
Entrez,  Source
N-ethylmaleimide-sensitive factor attachment protein, alpha11530.1400.1466Yes
9FCHO2FCHO2
Entrez,  Source
FCH domain only 211680.1390.1655Yes
10VPS4BVPS4B
Entrez,  Source
vacuolar protein sorting 4 homolog B (S. cerevisiae)11790.1380.1845Yes
11TRAPPC1TRAPPC1
Entrez,  Source
trafficking protein particle complex 115000.1270.1868Yes
12WASLWASL
Entrez,  Source
Wiskott-Aldrich syndrome-like15260.1260.2034Yes
13BET1BET1
Entrez,  Source
BET1 homolog (S. cerevisiae)16440.1230.2150Yes
14TMED2TMED2
Entrez,  Source
transmembrane emp24 domain trafficking protein 216600.1220.2316Yes
15VPS37AVPS37A
Entrez,  Source
vacuolar protein sorting 37 homolog A (S. cerevisiae)18850.1150.2369Yes
16AP2S1AP2S1
Entrez,  Source
adaptor-related protein complex 2, sigma 1 subunit19000.1140.2524Yes
17CTSZCTSZ
Entrez,  Source
cathepsin Z19150.1140.2678Yes
18TRAPPC6BTRAPPC6B
Entrez,  Source
trafficking protein particle complex 6B20880.1090.2749Yes
19CD59CD59
Entrez,  Source
CD59 molecule, complement regulatory protein22000.1060.2844Yes
20SEC23IPSEC23IP
Entrez,  Source
SEC23 interacting protein22360.1050.2976Yes
21SEC22BSEC22B
Entrez,  Source
SEC22 vesicle trafficking protein homolog B (S. cerevisiae)23530.1020.3064Yes
22CHMP4CCHMP4C
Entrez,  Source
chromatin modifying protein 4C23730.1020.3198Yes
23MCFD2MCFD2
Entrez,  Source
multiple coagulation factor deficiency 223860.1020.3336Yes
24SEC23ASEC23A
Entrez,  Source
Sec23 homolog A (S. cerevisiae)25690.0970.3385Yes
25TRAPPC5TRAPPC5
Entrez,  Source
trafficking protein particle complex 525770.0970.3518Yes
26COPB2COPB2
Entrez,  Source
coatomer protein complex, subunit beta 2 (beta prime)26720.0950.3607Yes
27CHMP4BCHMP4B
Entrez,  Source
chromatin modifying protein 4B27430.0930.3704Yes
28GOLPH3GOLPH3
Entrez,  Source
golgi phosphoprotein 3 (coat-protein)28100.0920.3801Yes
29PIK3C2APIK3C2A
Entrez,  Source
phosphoinositide-3-kinase, class 2, alpha polypeptide28610.0910.3905Yes
30F5F5
Entrez,  Source
coagulation factor V (proaccelerin, labile factor)29730.0880.3976Yes
31TSG101TSG101
Entrez,  Source
tumor susceptibility gene 10132070.0840.3980Yes
32TGFATGFA
Entrez,  Source
transforming growth factor, alpha32590.0830.4072Yes
33CHMP2ACHMP2A
Entrez,  Source
chromatin modifying protein 2A32670.0830.4185Yes
34SEC24DSEC24D
Entrez,  Source
SEC24 related gene family, member D (S. cerevisiae)32710.0820.4300Yes
35SEC24ASEC24A
Entrez,  Source
SEC24 related gene family, member A (S. cerevisiae)32730.0820.4415Yes
36TRAPPC3TRAPPC3
Entrez,  Source
trafficking protein particle complex 333260.0810.4505Yes
37SAR1BSAR1B
Entrez,  Source
SAR1 gene homolog B (S. cerevisiae)34370.0790.4563Yes
38HIP1HIP1
Entrez,  Source
huntingtin interacting protein 135080.0780.4638Yes
39SCFD1SCFD1
Entrez,  Source
sec1 family domain containing 135530.0770.4725Yes
40TRAPPC2TRAPPC2
Entrez,  Source
trafficking protein particle complex 236630.0750.4778Yes
41RILPRILP
Entrez,  Source
Rab interacting lysosomal protein37060.0740.4861Yes
42NSFNSF
Entrez,  Source
N-ethylmaleimide-sensitive factor37190.0730.4959Yes
43COPACOPA
Entrez,  Source
coatomer protein complex, subunit alpha38350.0710.5003Yes
44CHMP6CHMP6
Entrez,  Source
chromatin modifying protein 641230.0660.4956No
45KLHL12KLHL12
Entrez,  Source
kelch-like 12 (Drosophila)42520.0630.4983No
46EPS15EPS15
Entrez,  Source
epidermal growth factor receptor pathway substrate 1548400.0540.4772No
47PICALMPICALM
Entrez,  Source
phosphatidylinositol binding clathrin assembly protein50890.0500.4722No
48SERPINA1SERPINA1
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 152090.0480.4732No
49TMED9TMED9
Entrez,  Source
transmembrane emp24 protein transport domain containing 952530.0470.4778No
50S100A10S100A10
Entrez,  Source
S100 calcium binding protein A1052730.0470.4835No
51TRAPPC6ATRAPPC6A
Entrez,  Source
trafficking protein particle complex 6A59050.0380.4580No
52CSNK1DCSNK1D
Entrez,  Source
casein kinase 1, delta60130.0360.4580No
53PDCD6IPPDCD6IP
Entrez,  Source
programmed cell death 6 interacting protein60780.0360.4599No
54RAB1BRAB1B
Entrez,  Source
RAB1B, member RAS oncogene family61030.0350.4637No
55VPS28VPS28
Entrez,  Source
vacuolar protein sorting 28 homolog (S. cerevisiae)63420.0320.4566No
56VPS37CVPS37C
Entrez,  Source
vacuolar protein sorting 37 homolog C (S. cerevisiae)67560.0270.4402No
57COPB1COPB1
Entrez,  Source
coatomer protein complex, subunit beta 169660.0240.4334No
58LRSAM1LRSAM1
Entrez,  Source
leucine rich repeat and sterile alpha motif containing 171090.0220.4295No
59SNX3SNX3
Entrez,  Source
sorting nexin 371580.0210.4302No
60CHMP1BCHMP1B
Entrez,  Source
chromatin modifying protein 1B72210.0210.4301No
61TFGTFG
Entrez,  Source
TRK-fused gene73920.0180.4244No
62TRAPPC2LTRAPPC2L
Entrez,  Source
trafficking protein particle complex 2-like77470.0140.4092No
63FOLR1FOLR1
Entrez,  Source
folate receptor 1 (adult)78560.0130.4057No
64VAPAVAPA
Entrez,  Source
VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa81660.0080.3918No
65TRAPPC4TRAPPC4
Entrez,  Source
trafficking protein particle complex 481800.0080.3924No
66SEC31ASEC31A
Entrez,  Source
SEC31 homolog A (S. cerevisiae)86310.0030.3708No
67AREGAREG
Entrez,  Source
amphiregulin (schwannoma-derived growth factor)87060.0020.3675No
68GOLGA2GOLGA2
Entrez,  Source
golgi autoantigen, golgin subfamily a, 29199-0.0040.3440No
69VAPBVAPB
Entrez,  Source
VAMP (vesicle-associated membrane protein)-associated protein B and C9204-0.0040.3444No
70ARF1ARF1
Entrez,  Source
ADP-ribosylation factor 19245-0.0040.3430No
71FNBP1LFNBP1L
Entrez,  Source
formin binding protein 1-like9410-0.0060.3358No
72VPS37BVPS37B
Entrez,  Source
vacuolar protein sorting 37 homolog B (S. cerevisiae)9569-0.0080.3292No
73FCHO1FCHO1
Entrez,  Source
FCH domain only 19652-0.0080.3264No
74TMED10TMED10
Entrez,  Source
transmembrane emp24-like trafficking protein 10 (yeast)9658-0.0090.3273No
75PPP6CPPP6C
Entrez,  Source
protein phosphatase 6, catalytic subunit9978-0.0120.3135No
76LMAN1LMAN1
Entrez,  Source
lectin, mannose-binding, 110286-0.0150.3007No
77ANKRD28ANKRD28
Entrez,  Source
ankyrin repeat domain 2810295-0.0160.3025No
78ARCN1ARCN1
Entrez,  Source
archain 110472-0.0180.2964No
79CUL3CUL3
Entrez,  Source
cullin 310774-0.0210.2848No
80GORASP1GORASP1
Entrez,  Source
golgi reassembly stacking protein 1, 65kDa11260-0.0260.2648No
81ANXA2ANXA2
Entrez,  Source
annexin A211386-0.0280.2627No
82GBF1GBF1
Entrez,  Source
golgi-specific brefeldin A resistance factor 111953-0.0340.2399No
83VPS4AVPS4A
Entrez,  Source
vacuolar protein sorting 4 homolog A (S. cerevisiae)12218-0.0370.2323No
84CNIH2CNIH2
Entrez,  Source
cornichon homolog 2 (Drosophila)12922-0.0450.2044No
85COPZ1COPZ1
Entrez,  Source
coatomer protein complex, subunit zeta 113522-0.0510.1824No
86CHMP4ACHMP4A
Entrez,  Source
chromatin modifying protein 4A13561-0.0520.1879No
87TBC1D20TBC1D20
Entrez,  Source
TBC1 domain family, member 2014663-0.0650.1433No
88CTSCCTSC
Entrez,  Source
cathepsin C15317-0.0730.1218No
89COL7A1COL7A1
Entrez,  Source
collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive)15720-0.0780.1132No
90GOSR2GOSR2
Entrez,  Source
golgi SNAP receptor complex member 216666-0.0920.0802No
91GRIA1GRIA1
Entrez,  Source
glutamate receptor, ionotropic, AMPA 116920-0.0960.0814No
92SEC24CSEC24C
Entrez,  Source
SEC24 related gene family, member C (S. cerevisiae)17684-0.1080.0594No
93PREBPREB
Entrez,  Source
prolactin regulatory element binding17766-0.1100.0710No
94STX5STX5
Entrez,  Source
syntaxin 518695-0.1290.0439No
95ARFGAP1ARFGAP1
Entrez,  Source
ADP-ribosylation factor GTPase activating protein 119414-0.1490.0300No
96VPS37DVPS37D
Entrez,  Source
vacuolar protein sorting 37 homolog D (S. cerevisiae)20250-0.1980.0173No
Table: GSEA details [plain text format]



Fig 2: MEMBRANE BUDDING   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: MEMBRANE BUDDING: Random ES distribution   
Gene set null distribution of ES for MEMBRANE BUDDING