Genes in this set(5):
| Std. name | Sys. name | SGDID |
| NTG1 | YAL015C | S000000013 |
| APN2 | YBL019W | S000000115 |
| TDP1 | YBR223C | S000000427 |
| APN1 | YKL114C | S000001597 |
| NTG2 | YOL043C | S000005403 |
Enriched GO terms in this set:
GO:0008150 (biological_process)
"Those processes specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end."
GO:0050896 (response to stimulus)
"A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus."
GO:0006950 (response to stress) [p = 0.008 (5/237: NTG1; APN2; TDP1; APN1; NTG2)]
"A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)."
GO:0006974 (response to DNA damage stimulus) [p < 0.001 (5/120: NTG1; APN2; TDP1; APN1; NTG2)]
"A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism."
GO:0006281 (DNA repair) [p < 0.001 (5/88: NTG1; APN2; TDP1; APN1; NTG2)]
"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway."
GO:0006284 (base-excision repair) [p < 0.001 (4/5: NTG1; APN2; APN1; NTG2)]
"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase."
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GO:0003674 (molecular_function)
"Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions."
GO:0003824 (catalytic activity)
"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic."
GO:0016787 (hydrolase activity) [p = 0.005 (5/212: NTG1; APN2; TDP1; APN1; NTG2)]
"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3."
GO:0016798 (hydrolase activity, acting on glycosyl bonds)
"Catalysis of the hydrolysis of any glycosyl bond."
GO:0016799 (hydrolase activity, hydrolyzing N-glycosyl compounds) [p = 0.001 (2/2: NTG1; NTG2)]
"Catalysis of the hydrolysis of any N-glycosyl bond."
GO:0019104 (DNA N-glycosylase activity) [p = 0.001 (2/2: NTG1; NTG2)]
"Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site."
GO:0000702 (oxidized base lesion DNA N-glycosylase activity) [p = 0.001 (2/2: NTG1; NTG2)]
"Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site."
GO:0000703 (oxidized pyrimidine base lesion DNA N-glycosylase activity) [p = 0.001 (2/2: NTG1; NTG2)]
"Catalysis of the formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site. Enzymes with this activity recognize and remove oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar."
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GO:0008150 (biological_process)
"Those processes specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end."
GO:0009987 (cellular process)
"Processes that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level."
GO:0044237 (cellular metabolic process)
"The chemical reactions and pathways by which individual cells transform chemical substances."
GO:0006139 (nucleobase, nucleoside, nucleotide and nucleic acid metabolic process)
"The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids."
GO:0006259 (DNA metabolic process)
"The chemical reactions and pathways involving DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides."
GO:0006308 (DNA catabolic process)
"The chemical reactions and pathways resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one."
GO:0006285 (base-excision repair, AP site formation) [p = 0.001 (2/2: NTG1; NTG2)]
"The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired."
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GO:0003674 (molecular_function)
"Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions."
GO:0003824 (catalytic activity)
"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic."
GO:0016787 (hydrolase activity) [p = 0.005 (5/212: NTG1; APN2; TDP1; APN1; NTG2)]
"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3."
GO:0016788 (hydrolase activity, acting on ester bonds) [p < 0.001 (5/75: NTG1; APN2; TDP1; APN1; NTG2)]
"Catalysis of the hydrolysis of any ester bond."
GO:0004518 (nuclease activity) [p < 0.001 (4/28: NTG1; APN2; APN1; NTG2)]
"Catalysis of the hydrolysis of ester linkages within nucleic acids."
GO:0004536 (deoxyribonuclease activity) [p < 0.001 (4/18: NTG1; APN2; APN1; NTG2)]
"Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid."
GO:0004529 (exodeoxyribonuclease activity) [p = 0.007 (2/4: APN2; APN1)]
"Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule."
GO:0016895 (exodeoxyribonuclease activity, producing 5'-phosphomonoesters) [p = 0.003 (2/3: APN2; APN1)]
"Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters."
GO:0008309 (double-stranded DNA specific exodeoxyribonuclease activity) [p = 0.003 (2/3: APN2; APN1)]
"Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a double-stranded DNA molecule."
GO:0008311 (double-stranded DNA specific 3'-5' exodeoxyribonuclease activity) [p = 0.001 (2/2: APN2; APN1)]
"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule."
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GO:0008150 (biological_process)
"Those processes specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end."
GO:0009987 (cellular process)
"Processes that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level."
GO:0044237 (cellular metabolic process)
"The chemical reactions and pathways by which individual cells transform chemical substances."
GO:0006139 (nucleobase, nucleoside, nucleotide and nucleic acid metabolic process)
"The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids."
GO:0055086 (nucleobase, nucleoside and nucleotide metabolic process)
"The chemical reactions and pathways involving nucleobases, nucleosides and nucleotides."
GO:0009117 (nucleotide metabolic process)
"The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)."
GO:0009166 (nucleotide catabolic process) [p = 0.001 (2/2: NTG1; NTG2)]
"The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)."
GO:0009264 (deoxyribonucleotide catabolic process) [p = 0.001 (2/2: NTG1; NTG2)]
"The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety."
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GO:0003674 (molecular_function)
"Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions."
GO:0003824 (catalytic activity)
"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic."
GO:0016787 (hydrolase activity) [p = 0.005 (5/212: NTG1; APN2; TDP1; APN1; NTG2)]
"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3."
GO:0016788 (hydrolase activity, acting on ester bonds) [p < 0.001 (5/75: NTG1; APN2; TDP1; APN1; NTG2)]
"Catalysis of the hydrolysis of any ester bond."
GO:0042578 (phosphoric ester hydrolase activity)
"Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3."
GO:0008081 (phosphoric diester hydrolase activity) [p < 0.001 (3/8: APN2; TDP1; APN1)]
"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group."
GO:0017005 (tyrosyl-DNA phosphodiesterase activity) [p = 0.001 (2/2: TDP1; APN1)]
"Catalysis of the hydrolysis of covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA."
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