Genes in this set(25):
| Std. name | Sys. name | SGDID |
| HPC2 | YBR215W | S000000419 |
| SLX8 | YER116C | S000000918 |
| RAD24 | YER173W | S000000975 |
| RPL27A | YHR010W | S000001052 |
| RAD59 | YDL059C | S000002217 |
| XRS2 | YDR369C | S000002777 |
| RAD54 | YGL163C | S000003131 |
| SAE2 | YGL175C | S000003143 |
| GRR1 | YJR090C | S000003850 |
| AAT2 | YLR027C | S000004017 |
| RNH203 | YLR154C | S000004144 |
| MEC3 | YLR288C | S000004279 |
| | YLR352W | S000004344 |
| SFP1 | YLR403W | S000004395 |
| CAC2 | YML102W | S000004570 |
| MRE11 | YMR224C | S000004837 |
| PEP5 | YMR231W | S000004844 |
| RNH201 | YNL072W | S000005016 |
| HST3 | YOR025W | S000005551 |
| EXO1 | YOR033C | S000005559 |
| RPS30B | YOR182C | S000005708 |
| UAF30 | YOR295W | S000005821 |
| RAD17 | YOR368W | S000005895 |
| | YPR116W | S000006320 |
| NAT3 | YPR131C | S000006335 |
Enriched GO terms in this set:
GO:0003674 (molecular_function)
"Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions."
GO:0005488 (binding)
"The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule."
GO:0003676 (nucleic acid binding)
"Interacting selectively with any nucleic acid."
GO:0003677 (DNA binding) [p = 0.001 (9/88: RAD59; XRS2; RAD54; MEC3; SFP1; MRE11; HST3; UAF30; RAD17)]
"Interacting selectively with DNA (deoxyribonucleic acid)."
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GO:0008150 (biological_process)
"Those processes specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end."
GO:0009987 (cellular process)
"Processes that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level."
GO:0044237 (cellular metabolic process)
"The chemical reactions and pathways by which individual cells transform chemical substances."
GO:0006139 (nucleobase, nucleoside, nucleotide and nucleic acid metabolic process) [p = 0.008 (19/568: HPC2; SLX8; RAD24; RAD59; XRS2; RAD54; SAE2; RNH203; MEC3; SFP1; CAC2; MRE11; RNH201; HST3; EXO1; RPS30B; UAF30; RAD17; NAT3)]
"The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids."
GO:0006259 (DNA metabolic process) [p = 0.001 (17/384: HPC2; SLX8; RAD24; RAD59; XRS2; RAD54; SAE2; RNH203; MEC3; CAC2; MRE11; RNH201; HST3; EXO1; RPS30B; RAD17; NAT3)]
"The chemical reactions and pathways involving DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides."
GO:0006281 (DNA repair) [p = 0.001 (9/88: RAD24; RAD59; XRS2; RAD54; SAE2; CAC2; MRE11; EXO1; RAD17)]
"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway."
GO:0000726 (non-recombinational repair) [p = 0.004 (5/21: RAD59; XRS2; SAE2; MRE11; EXO1)]
"The repair of damaged DNA that does not require the exchange of genetic material between the broken DNA molecule and a homologous region of DNA."
GO:0045002 (double-strand break repair via single-strand annealing) [p = 0.001 (4/8: RAD59; SAE2; MRE11; EXO1)]
"Repair of a DSB made between two repeated sequences oriented in the same direction occurs primarily by the single strand annealing pathway. The ends of the break are processed by a 5' to 3' exonuclease, exposing complementary single-strand regions of the direct repeats that can anneal, resulting in a deletion of the unique DNA between the direct repeats."
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GO:0003674 (molecular_function)
"Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions."
GO:0005488 (binding)
"The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule."
GO:0003676 (nucleic acid binding)
"Interacting selectively with any nucleic acid."
GO:0003677 (DNA binding) [p = 0.001 (9/88: RAD59; XRS2; RAD54; MEC3; SFP1; MRE11; HST3; UAF30; RAD17)]
"Interacting selectively with DNA (deoxyribonucleic acid)."
GO:0043566 (structure-specific DNA binding)
"Interacting selectively with DNA of a specific structure or configuration e.g. triplex DNA binding or bent DNA binding."
GO:0003690 (double-stranded DNA binding) [p = 0.003 (4/9: RAD59; XRS2; MRE11; RAD17)]
"Interacting selectively with double-stranded DNA."
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GO:0008150 (biological_process)
"Those processes specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end."
GO:0009987 (cellular process)
"Processes that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level."
GO:0044237 (cellular metabolic process)
"The chemical reactions and pathways by which individual cells transform chemical substances."
GO:0006139 (nucleobase, nucleoside, nucleotide and nucleic acid metabolic process) [p = 0.008 (19/568: HPC2; SLX8; RAD24; RAD59; XRS2; RAD54; SAE2; RNH203; MEC3; SFP1; CAC2; MRE11; RNH201; HST3; EXO1; RPS30B; UAF30; RAD17; NAT3)]
"The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids."
GO:0006259 (DNA metabolic process) [p = 0.001 (17/384: HPC2; SLX8; RAD24; RAD59; XRS2; RAD54; SAE2; RNH203; MEC3; CAC2; MRE11; RNH201; HST3; EXO1; RPS30B; RAD17; NAT3)]
"The chemical reactions and pathways involving DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides."
GO:0006310 (DNA recombination) [p < 0.001 (9/62: RAD24; RAD59; XRS2; RAD54; SAE2; MEC3; MRE11; EXO1; RAD17)]
"The processes by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction."
GO:0000725 (recombinational repair) [p < 0.001 (6/18: RAD59; XRS2; RAD54; SAE2; MRE11; EXO1)]
"The repair of damaged DNA that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA."
GO:0000724 (double-strand break repair via homologous recombination) [p < 0.001 (6/16: RAD59; XRS2; RAD54; SAE2; MRE11; EXO1)]
"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule."
GO:0045003 (double-strand break repair via synthesis-dependent strand annealing) [p = 0.004 (4/10: RAD54; SAE2; MRE11; EXO1)]
"SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break."
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GO:0008150 (biological_process)
"Those processes specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end."
GO:0009987 (cellular process)
"Processes that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level."
GO:0044237 (cellular metabolic process)
"The chemical reactions and pathways by which individual cells transform chemical substances."
GO:0006139 (nucleobase, nucleoside, nucleotide and nucleic acid metabolic process) [p = 0.008 (19/568: HPC2; SLX8; RAD24; RAD59; XRS2; RAD54; SAE2; RNH203; MEC3; SFP1; CAC2; MRE11; RNH201; HST3; EXO1; RPS30B; UAF30; RAD17; NAT3)]
"The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids."
GO:0006259 (DNA metabolic process) [p = 0.001 (17/384: HPC2; SLX8; RAD24; RAD59; XRS2; RAD54; SAE2; RNH203; MEC3; CAC2; MRE11; RNH201; HST3; EXO1; RPS30B; RAD17; NAT3)]
"The chemical reactions and pathways involving DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides."
GO:0006308 (DNA catabolic process) [p = 0.008 (4/12: XRS2; SAE2; MRE11; EXO1)]
"The chemical reactions and pathways resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one."
GO:0000738 (DNA catabolic process, exonucleolytic) [p = 0.007 (3/4: SAE2; MRE11; EXO1)]
"The hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides."
GO:0000729 (DNA double-strand break processing) [p = 0.007 (3/4: SAE2; MRE11; EXO1)]
"The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang."
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