Genes in this set(6):
| Std. name | Sys. name | SGDID |
| RAD18 | YCR066W | S000000662 |
| RAD51 | YER095W | S000000897 |
| XRS2 | YDR369C | S000002777 |
| RAD54 | YGL163C | S000003131 |
| EST2 | YLR318W | S000004310 |
| MRE11 | YMR224C | S000004837 |
Enriched GO terms in this set:
GO:0008150 (biological_process)
"Those processes specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end."
GO:0009987 (cellular process)
"Processes that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level."
GO:0044237 (cellular metabolic process)
"The chemical reactions and pathways by which individual cells transform chemical substances."
GO:0006139 (nucleobase, nucleoside, nucleotide and nucleic acid metabolic process)
"The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids."
GO:0006259 (DNA metabolic process)
"The chemical reactions and pathways involving DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides."
GO:0006310 (DNA recombination) [p = 0.003 (4/62: RAD51; XRS2; RAD54; MRE11)]
"The processes by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction."
GO:0000725 (recombinational repair) [p < 0.001 (4/18: RAD51; XRS2; RAD54; MRE11)]
"The repair of damaged DNA that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA."
GO:0000724 (double-strand break repair via homologous recombination) [p < 0.001 (4/16: RAD51; XRS2; RAD54; MRE11)]
"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule."
GO:0045003 (double-strand break repair via synthesis-dependent strand annealing) [p = 0.002 (3/10: RAD51; RAD54; MRE11)]
"SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break."
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GO:0003674 (molecular_function)
"Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions."
GO:0003824 (catalytic activity)
"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic."
GO:0016787 (hydrolase activity)
"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3."
GO:0016817 (hydrolase activity, acting on acid anhydrides)
"Catalysis of the hydrolysis of any acid anhydride."
GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides)
"Catalysis of the hydrolysis of any acid anhydride which contains phosphorus."
GO:0016462 (pyrophosphatase activity)
"Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments."
GO:0017111 (nucleoside-triphosphatase activity)
"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate."
GO:0016887 (ATPase activity)
"Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction."
GO:0042623 (ATPase activity, coupled)
"Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive some other reaction, for example ion transport across a membrane."
GO:0008094 (DNA-dependent ATPase activity) [p = 0.002 (3/11: RAD18; RAD51; RAD54)]
"Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single- or double-stranded DNA; drives another reaction."
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GO:0003674 (molecular_function)
"Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions."
GO:0005488 (binding)
"The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule."
GO:0003676 (nucleic acid binding) [p = 0.003 (5/140: RAD18; XRS2; RAD54; EST2; MRE11)]
"Interacting selectively with any nucleic acid."
GO:0003677 (DNA binding) [p = 0.001 (5/88: RAD18; XRS2; RAD54; EST2; MRE11)]
"Interacting selectively with DNA (deoxyribonucleic acid)."
GO:0043565 (sequence-specific DNA binding) [p = 0.003 (3/18: XRS2; EST2; MRE11)]
"Interacting selectively with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding."
GO:0042162 (telomeric DNA binding) [p < 0.001 (3/7: XRS2; EST2; MRE11)]
"Interacting selectively with telomere-associated DNA, usually characterized by highly repetitive sequences."
GO:0003691 (double-stranded telomeric DNA binding) [p = 0.007 (2/3: XRS2; MRE11)]
"Interacting selectively with double-stranded telomere-associated DNA."
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GO:0005575 (cellular_component)
"The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together."
GO:0044422 (organelle part)
"Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane."
GO:0044446 (intracellular organelle part)
"A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane."
GO:0044428 (nuclear part)
"Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated."
GO:0030870 (Mre11 complex) [p = 0.007 (2/3: XRS2; MRE11)]
"Trimeric protein complex that possesses endonuclease activity; involved in DNA repair and checkpoint signaling. In Saccharomyces the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins related to the Saccharomyces proteins."
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GO:0003674 (molecular_function)
"Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions."
GO:0005488 (binding)
"The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule."
GO:0003676 (nucleic acid binding) [p = 0.003 (5/140: RAD18; XRS2; RAD54; EST2; MRE11)]
"Interacting selectively with any nucleic acid."
GO:0003677 (DNA binding) [p = 0.001 (5/88: RAD18; XRS2; RAD54; EST2; MRE11)]
"Interacting selectively with DNA (deoxyribonucleic acid)."
GO:0043566 (structure-specific DNA binding) [p = 0.003 (3/19: RAD18; XRS2; MRE11)]
"Interacting selectively with DNA of a specific structure or configuration e.g. triplex DNA binding or bent DNA binding."
GO:0003697 (single-stranded DNA binding) [p = 0.002 (3/14: RAD18; XRS2; MRE11)]
"Interacting selectively with single-stranded DNA."
GO:0043047 (single-stranded telomeric DNA binding) [p = 0.007 (2/3: XRS2; MRE11)]
"Interacting selectively with single-stranded telomere-associated DNA."
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GO:0003674 (molecular_function)
"Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions."
GO:0005488 (binding)
"The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule."
GO:0003676 (nucleic acid binding) [p = 0.003 (5/140: RAD18; XRS2; RAD54; EST2; MRE11)]
"Interacting selectively with any nucleic acid."
GO:0003677 (DNA binding) [p = 0.001 (5/88: RAD18; XRS2; RAD54; EST2; MRE11)]
"Interacting selectively with DNA (deoxyribonucleic acid)."
GO:0043566 (structure-specific DNA binding) [p = 0.003 (3/19: RAD18; XRS2; MRE11)]
"Interacting selectively with DNA of a specific structure or configuration e.g. triplex DNA binding or bent DNA binding."
GO:0051880 (G-quadruplex DNA binding) [p = 0.007 (2/3: XRS2; MRE11)]
"Interacting selectively with G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome."
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GO:0008150 (biological_process)
"Those processes specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end."
GO:0009987 (cellular process)
"Processes that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level."
GO:0048869 (cellular developmental process) [p = 0.008 (4/71: RAD51; XRS2; RAD54; MRE11)]
"A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition."
GO:0030154 (cell differentiation) [p = 0.008 (4/71: RAD51; XRS2; RAD54; MRE11)]
"The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate."
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